Activation of the body’s cannabinoid receptors – which is done naturally through the consumption of cannabis – may promote bone formation and reduce bone dissolution, according to a study published this month in the journal Molecular and Cellular Biochemistry, and published online by the U.S. National Institute of Health.

“The type-2 cannabinoid receptor (CB2) is expressed in osteoblasts and plays a role in bone metabolism through regulation on bone mass and bone turnover”, begins the study’s abstract; “but the functional importance of CB2 in osteoblasts under Titanium (Ti) stimulation is incompletely understood.”

For the study, researchers “aimed to investigate the CB2 expression in osteoblasts under Ti stimulation and the effects of CB2 activation on proliferation, apoptosis, differentiation, mineralization, OPG, and RANKL expression of MC3T3-E1 cells exposed to Ti particles.”

After conducting the study, researchers found that “CB2 activation has a favorable inhibitory effect on Ti-induced reactions in MC3T3-E1 cell through modulating proliferation, apoptosis, differentiation, and RANKL expression.”

The study concludes; “These findings suggest that activation of CB2 might be an effective therapeutic strategy to promote bone formation and reduce bone dissolution.”

The study, which was conducted by researchers at Xuzhou Medical College in Jiangsu, China, can be found by clicking here.


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