According to researchers; “A central feature of osteoarthritis (OA) is the loss of articular cartilage, which is primarily attributed to cartilage breakdown.” The current study explored the effects of a synthetic cannabinoid meant to mimic the effects of cannabis-based cannabinoids on preventing this breakdown.
“In conclusion, to the best of our knowledge, the present study provides the first in vitro evidence supporting that the synthetic cannabinoid WIN‑55 inhibits ADAMTS‑4 activity in unstimulated and IL‑1β‑stimulated human OA articular chondrocytes by decreasing the mRNA stability/expression of syndecan‑1 via CB2.”
According to researchers; “This suggests a novel mechanism by which cannabinoids may prevent cartilage breakdown in OA. In addition, it also provides novel insights into the pharmacological effects of synthetic cannabinoids on OA.”
The study, conducted by researchers at Second Xiangya Hospital at Central South University in China, can be found by clicking here.
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