cannabis compound cannabidiol, often referred to simply as CBD, may provide a potential treatment for acne.
For the study, researchers used cannabidiol derived from cannabis on human sebaceous gland function, and determined that CBD behaves as a highly effective sebostatic agent.
“Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels”, claims researchers.
They continue; “Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling.”
The study concludes; “Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.”
The research can be found on the National Library of Medicine’s website by clicking here.
The post Cannabidiol May Treat Acne, Finds Study appeared first on The Joint Blog.
Read this full story…..: Cannabidiol May Treat Acne, Finds Study