Month: March 2018

Op-ed: Hemp never belonged on the controlled-substances list

Attorney General Jeff Sessions does not like marijuana, and the feds could crack down on Colorado’s booming industry at any time. But hemp has a powerful ally in Washington: Senate Majority Leader Mitch McConnel. It is past time for Washington to let farmers grow hemp without fear.

The post Op-ed: Hemp never belonged on the controlled-substances list appeared first on The Cannabist.

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Study: Cannabis Could Represent an Effective and Well-Tolerated Treatment for Epileptic Seizures

According to a new study published by Epilepsia Open, “cannabis could actually represent an effective, well-tolerated antiepileptic drug”.

“Cannabidivarin (CBDV) and cannabidiol (CBD) have recently emerged among cannabinoids for their potential antiepileptic properties, as shown in several animal models”, states the study’s abstract. “We report the case of a patient affected by symptomatic partial epilepsy who used cannabis as self-medication after the failure of countless pharmacological/surgical treatments.”

Clinical and video electroencephalogram (EEG) evaluations were periodically performed, and the serum levels of CBDV, CBD, and Δ9-tetrahydrocannabinol were repeatedly measured. After cannabis administration, “a dramatic clinical improvement, in terms of both decrease in seizure frequency and recovery of cognitive functions, was observed, which might parallel high CBDV plasma concentrations.”

To widen the spectrum of CBDV possible mechanisms of action, “electrophysiological methods were applied to investigate whether it could exert some effects on γ-aminobutyric acid (GABA)A receptors.”

According to the study; “Our experiments showed that, in human hippocampal tissues of four patients affected by drug-resistant temporal lobe epilepsy (TLE) transplanted in Xenopus oocytes, there is decrease of current rundown (i.e., reduction of use-dependent GABAA current) after prolonged exposure to CBDV. This result has been confirmed using a single case of Rasmussen encephalitis (RE).”

They conclude by stating that; “Our patient’s electroclinical improvement supports the hypothesis that cannabis could actually represent an effective, well-tolerated antiepileptic drug. Moreover, the experimental data suggest that CBDV may greatly contribute to cannabis anticonvulsant effect through its possible GABAergic action.”

For the full study, click here.

The post Study: Cannabis Could Represent an Effective and Well-Tolerated Treatment for Epileptic Seizures appeared first on TheJointBlog.

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