THC May Treat Spasticity and Pain Associated with Multiple Sclerosis, According to New Research

The oral administration of Δ9-tetrahydrocannabinol (THC) may treat both spasticity and pain associated with multiple sclerosis.

This is according to a study being published by the journal Clinical Therapeutics, and e-published ahead of print by the U.S. National Institute of Health.

According to the Mayo Clinic, multiple sclerosis (MS) is a “disease in which the immune system eats away at the protective covering of nerves.” The ailment affects around 200,000 people annually and has no cure. Multiple sclerosis causes many different symptoms, including vision loss, pain, fatigue, and impaired coordination.

The aim of the present study was to “evaluate the efficacy of an oral formulation of Δ9-tetrahydrocannabinol (ECP002A) in patients with progressive multiple sclerosis (MS).”

Researchers used an accelerated proof-of-concept study that consisted of “2 phases: a crossover challenge (dose-finding) phase and a 4-week, parallel, randomized, placebo-controlled treatment phase.”

24 patients with progressive MS and moderate spasticity were enrolled. During the treatment phase, “biomarkers for efficacy and secondary pharmacodynamic effects were measured at baseline and after 2 and 4 weeks of treatment. Serum samples were collected to determine pharmacokinetic properties and perform population modeling. Safety and tolerability profiles were assessed based on adverse events and safety measurements.”

After conducting the experiments, it was found that “Pain was significantly reduced when measured directly after administration of ECP002A in the clinic but not when measured in a daily diary. A similar pattern was observed in subjective muscle spasticity.”

Cognitive testing indicated that there was “no decline in cognition after 2 or 4 weeks of treatment attributable to ECP002A compared with placebo.”

Researchers conclude by stating that the “oral formulation of Δ9-tetrahydrocannabinol may play a role in the treatment of spasticity and pain associated with MS because it was well tolerated and had a stable pharmacokinetic profile.”

Click here for the full study, which was conducted by researchers at VU University Medical Center and the Centre for Human Drug Research, both in the Netherlands.

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Study Finds CBD May Treat Alcohol Use Disorders

New findings “strongly suggest” that cannabidiol (CBD) may be useful in the treatment of alcohol use disorders.

The study, published by the journal Addiction Biology, “evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse” in mice.” The effects of “CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated.”

Researchers used the two-bottle choice paradigm to assess the effects of CBD (30, 60 and 120 mg/kg/day, i.p) on ethanol intake and preference. In addition, “an oral ethanol self-administration experiment was carried out to evaluate the effects of CBD [a single s.c. administration of a microparticle formulation providing CBD continuous controlled release (30 mg/kg/day)] on the reinforcement and motivation for ethanol. The effects of CBD (60 and 120 mg/kg/day, i.p.) on ethanol-induced relapse were also evaluated.”

In conducting these tests, researchers found that cannabidiol “reduced the ethanol-induced hypothermia and handling-induced convulsion, and “reduced ethanol consumption and preference in the two-bottle choice, significantly decreased ethanol intake and the number of effective responses in the oral ethanol self-administration, and reduced ethanol-induced relapse.”

Furthermore, “the administration of CBD significantly reduced relative gene expression of tyrosine hydroxylase in the ventral tegmental area, Oprm1, CB1 r and GPR55 in the NAcc and significantly increased CB2 r in the NAcc.”

Taken together, “these results reveal that the administration of CBD reduced the reinforcing properties, motivation and relapse for ethanol.”

The study concludes; “These findings strongly suggest that CBD may result useful for the treatment of alcohol use disorders.”

According to the Mayo Clinic, an alcohol use disorder is “a chronic disease characterized by uncontrolled drinking and preoccupation with alcohol.”

The study was published online by the U.S. National Institute of Health as well as Addiction Biology; it can be found by clicking here.

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Hawaii Committee Unanimously Passes Bill to Legalize Hemp with No License Required

A bill that would treat hemp like other crops such as tomatoes, allowing it to be grown by anyone without a license, has been approved by its initial committee in Hawaii.

The House Agricultural Committee approved House Bill 773 with a unanimous 7 to 0 vote. The measure makes it so that “No person shall be subject to any civil or criminal sanctions in this State for planting, growing, harvesting, possessing, processing, selling, or buying industrial hemp”. Hemp would be defined as having no more than 0.3% tetrahydrocannabinol (THC, the active ingredient in cannabis).

The proposal is now in the House Judiciary Committee, where passage would set it up for a vote in the full House. Passage by the full House would sent it to the Senate, where approval would put it to the desk of Governor David Ige for final consideration.

Click here for the full text of House Bill 773.

Last month Speaker of the House Joseph M. Souki filed a bill that would fully legalize the recreational use of cannabis; this includes personal cultivation and licensed cannabis retail outlets.

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Marijuana Strain Overview: Strawberry Lemonade

Strawberry Lemonade is a great day-time use sativa that’s a mix between Strawberry Cough and Lemon OG.

(Photo: MedicalJane.com)

Strawberry Lemonade, a sativa-dominant strain, has an uplifting, almost energetic high to it that buzzes throughout the entire body. The taste is great, and perfectly matches its name. As one reviewer (deadlightbulb) on Leafly puts it, it’s like “a tornado made it way through a strawberry field, lemon tree farm and directly into my mouth.”

A concentrate made from the Strawberry Lemonade strain took 1st in High Times’ 2015 Denver Cannabis Cup as “Best Sativa Concentrate”.

This strain is great for those suffering from chronic pain, stress, depression, lack of appetite or anxiety.

Smell and taste:

  • Ripe strawberry
  • Tart lemonade

Reviews:

Strawberry Lemonade currently has 82 reviews on Leafly with an average score of 4.1 out of 5.

Highlighted quote (from one of the Leafly reviews):

“This strain tastes is like a tornado made it way through a strawberry field, lemon tree farm and directly into my mouth. I can’t believe how much flavor this packs! Such a tantalizing terpene profile for this sativa. It is a powerfully uplifting sativa that will give you a very nice cerebral buzz. It was a bit harsh and did make me cough, but the aftertaste was like exhaling a sweetened lemon zest.”

Where to find it

If you live in a state where cannabis is legal, Leafly has a strain finder that can use your exact location to find the closet cannabis store or dispensary to you that is currently carrying then Strawberry Lemonade marijuana strain; you can also look for a variety of other strains.

Click here for this strain finder.

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